In a Man of the match performance on 28 December 2015 in a 2–1 win, Antonio scored his first goal for West Ham. With the team losing 1–0 to Southampton, Antonio equalised when a clearance hit him and looped over Southampton goalkeeper, Maarten Stekelenburg.[46]
On 1 September 2015, Antonio signed for West Ham United for around £7 million on a four-year contract with an option for a further two years.[44] He made his debut on 19 September, replacing Victor Moses in the 60th minute of West Ham's 2–1 Premier League win at Manchester City.[45]
On 27 February, Antonio scored the only goal in a home win over Sunderland. He celebrated by lying on his side and spinning in a circle, imitating a celebration by The Simpsons character Homer Simpson in the episode